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Tandem CAR and single CAR T cells have different fates and therapeutic potency

ABSTRACT: Chimeric antigen receptor T (CAR T) cells targeting CD19 have achieved breakthroughs in the treatment of haematological malignancies, but many clinical studies have also shown that a proportion of patients relapse after remission. In this study, we designed a series of tandem CARs (TanCARs) and found that TanCAR7 T cells retained relatively potent antitumour activity compared with single CAR T cell upon target antigen recognition. It may be associated with stable immunological synapse formation and rapid degranulation. Our transcriptional analysis underscores the potential of scFv domains binding to direct different T cell fates.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134937 | GEO | 2020/06/30

REPOSITORIES: GEO

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