Bach2 deficiency leads to spontaneous expansion of IL-4-producing T follicular helper cells and autoimmunity
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ABSTRACT: The transcription factor Bach2 is a critical negative regulator of Tfh cell differentiation, especially IL-4 subset. Tfh cells from the mesenteric lymph nodes of WT and Bach2 CD4 conditional KO mice were collected to process the Rna-seq. Mechanistically, Bach2 may limit abnormal IL-4-produicng Tfh cell formation by repressing c-Maf, CXCR5 and IL-4.
ORGANISM(S): Mus musculus
PROVIDER: GSE135087 | GEO | 2021/01/26
REPOSITORIES: GEO
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