Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential mRNA expression upon 9p21 deletion in HEK TE single-cell derived clones

ABSTRACT: RNA sequencing was performed to identify mRNAs that are dysregulated upon loss of 9p21. Subsequently, the effect on cell transformation was investigated upon knockdown/overexpression of the candidate targets found from the RNA sequencing analysis .

ORGANISM(S): Homo sapiens

PROVIDER: GSE135716 | GEO | 2019/08/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Differential mRNA expression upon 9p21 deletion in HEK TE single-cell derived clones

Project description:Differential mRNA expression upon 9p21 deletion in HEK TE single-cell derived clones

| PRJNA559840 | ENA

4C analysis of 9p21 interaction network in HEK TE cells

Project description:4C was performed to identify genomic loci interacting with the 9P21 locus. Subsequently, the effect on cell transformation was furhter investigated upon knockdown/overexpression of the selected candidate targets.

2019-08-13 | GSE135715 | GEO

4C analysis of 9p21 interaction network in HEK TE cells

Project description:4C analysis of 9p21 interaction network in HEK TE cells

| PRJNA559841 | ENA

miR-876 is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK

Project description:While melanomas commonly harbor losses of 9p21, on which CDKN2A resides, the presence of additional tumor suppressor elements at this locus is incompletely characterized. Here we assess the expression levels and functional role of microRNA-876 (miR-876), whose gene also maps to 9p21.

2024-08-21 | GSE267789 | GEO

Differential lncRNA expression upon hypoxia affects splicing efficiency

Project description:RNA sequencing was performed to identify long non-coding RNAs that are dysregulated upon hypoxia in breast cancer. Subsequently, the effect on splicing effiency (intron retention, exon skipping …) was investigated from RNA sequencing analysis upon knockdown of the candidate lncRNA and upon hypoxia.

2019-04-05 | GSE129344 | GEO

Haplodeficiency of the 9p21 Tumor Suppressor Locus Causes Myeloid Disorders Driven by Bone Marrow Microenvironment

Project description:The chromosome 9p21 locus comprises several tumor suppressor genes including MTAP, CDKN2A and CDKN2B, and its homo- or heterozygous deletions are associated with reduced survival in multiple cancer types. We report that mice with germline monoallelic deletion or induced biallelic deletion of the 9p21-syntenic locus (9p21s) developed fatal myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN)-like disease associated with aberrant trabecular bone formation and/or fibrosis in the bone marrow (BM). Reciprocal BM transfers and conditional targeting of 9p21s suggested that the disease originates in the BM stroma. Single-cell analysis of 9p21s-deficient BM stroma revealed the expansion of chondrocyte and osteogenic precursors, reflected in increased osteogenic differentiation in vitro. It also showed reduced expression of factors maintaining hematopoietic stem/progenitor cells, including Cxcl12. Accordingly, 9p21s-deficient mice showed reduced levels of circulating Cxcl12 and a concomitant upregulation of the pro-fibrotic chemokine Cxcl13. Our study highlights the potential of mutations in the BM microenvironment to drive MDS/MPN-like disease. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at two time points.

2023-06-06 | GSE211779 | GEO

Differential Gene Expression Upon PFN1 Deletion

Project description:Differential Gene Expression Upon PFN1 Deletion

| PRJNA630391 | ENA

Transcriptome of ESCs upon MLL1 inhibition/deletion

Project description:Transcriptome of ESCs upon MLL1 inhibition/deletion

| PRJNA420025 | ENA

Loss of 9p21 regulatory hub promotes kidney cancer progression by upregulating HOXB13

Project description:Loss of 9p21 regulatory hub promotes kidney cancer progression by upregulating HOXB13

| PRJNA559845 | ENA

Epigenetic landscape of HEK cells upon epithelial-to-mesenchymal transition

Project description:Epigenetic landscape of HEK cells upon epithelial-to-mesenchymal transition