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The lncRNA RUNX1-IT1 promotes pancreatic cancer progression by inducing C-FOS expression

ABSTRACT: The functional analysis of RUNX1-IT1 in tumors is relatively lacking, and its role and mechanism in pancreatic have not been reported. RUNX1-IT1 is transcribed from the intron of the RUNX1 gene, which plays an important role in solid tumors, and its abnormal expression is closely associated with cancer progression. However, due to the lack of systematic research, the regulatory mechanism and important downstream targets of RUNX1-IT1 and RUNX1 in PC are unclear. To investigate the downstream pathway of RUNX1-IT1 and RUNX1, we performed RNA-seq using two PANC-1 cell groups: RUNX1-IT1 knockdown and control, and RUNX1 knockdown and control.

ORGANISM(S): Homo sapiens

PROVIDER: GSE135783 | GEO | 2022/08/13

REPOSITORIES: GEO

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