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Stat1-induced NAMPT sustains glycolysis to regulate gene expression in classically activated macrophages

ABSTRACT: Single Cell RNA Sequencing is used to profile in vivo responses by immune cells lacking the Nampt NRE1 region to melanoma challenge, finding multiple defects in macrophages and other myeloid APCs. We analyzed B16F10 melanoma tumor infiltrating immune cells from mice specifically lacking NRE1 in hematopoietic cells, finding inflammatory and metabolic defects in APC populations within tumors, correlating with trends toward defective control of malignant growth.

ORGANISM(S): Mus musculus

PROVIDER: GSE135814 | GEO | 2019/10/01

REPOSITORIES: GEO

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