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Use of spermatozoal total RNA profiles to study gene-environment interactions in human germ cells

ABSTRACT: Paternal exposure to genotoxic compounds is thought to contribute to diseases in their offspring. Therefore, mRNA profiles from sperm in ejaculates of cigarette smokers (N=4) were compared with non-smokers (N=4). Smoking behaviour was verified by assessing cotinine levels in seminal plasma. Gene-expression analysis was subsequently performed using microarray technology (Agilent human 4x44k) to investigate the use of gene-expression profiling as biomarker of gene-environment interactions in human testis

ORGANISM(S): Homo sapiens

PROVIDER: GSE13600 | GEO | 2009/01/28

SECONDARY ACCESSION(S): PRJNA110217

REPOSITORIES: GEO

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The gene expression signature of chronic marijuana use

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