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Age, sexual dimorphism and disease associations in the developing human fetal lung transcriptome

ABSTRACT: Whole human fetal lung transcriptome profiles from estimated gestational ages 54 to 137 days post conception. Maternal cigarette smoking status is indicated by cotinine levels measured in the corresponding placenta. Time series with biological replicates. Whole lung transcriptome profiles, lung development, human fetus, in utero cigarette smoke exposure

ORGANISM(S): Homo sapiens

SUBMITTER: Alvin Kho

PROVIDER: E-GEOD-68896 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.

Kho Alvin T AT Chhabra Divya D Sharma Sunita S Qiu Weiliang W Carey Vincent J VJ Gaedigk Roger R Vyhlidal Carrie A CA Leeder J Steven JS Tantisira Kelan G KG Weiss Scott T ST

American journal of respiratory cell and molecular biology 20160601 6

The fetal origins of disease hypothesis suggests that variations in the course of prenatal lung development may affect life-long pulmonary function growth, decline, and pathobiology. Many studies support the existence of differences in the developing lung trajectory in males and females, and sex-specific differences in the prevalence of chronic lung diseases, such as asthma and bronchopulmonary dysplasia. The objectives of this study were to investigate the early developing fetal lung for transc ...[more]

PMID: 26584061

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