Methylation profiling

Dataset Information

0

Reduced representative bisulfite sequencing (RRBS) analysis for a genome-wide comparison of DNA methylation in wild-type, USP7-KO-1, DNMT3A/3B-DKO and DNMT3A/DNMT3B/USP7-TKO HeLa cell lines.


ABSTRACT: To better characterize the effects of USP7 on DNA methylation, we performed reduced representative bisulfite sequencing (RRBS) analysis for a genome-wide comparison of DNA methylation in wild-type, USP7-KO-1, DNMT3A/3B-DKO and DNMT3A/DNMT3B/USP7-TKO HeLa cell lines. RRBS analysis showed increased DNA methylation in USK7-KO cells and loss of USP7 elevates DNA methylation on pre-existing sites and de novo methylation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136159 | GEO | 2020/09/07

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA561408 | ENA
2015-03-30 | E-GEOD-63280 | biostudies-arrayexpress
2021-10-07 | GSE183480 | GEO
2021-10-07 | GSE184443 | GEO
2014-11-14 | E-GEOD-60334 | biostudies-arrayexpress
2011-10-25 | E-GEOD-32487 | biostudies-arrayexpress
2019-04-01 | GSE97340 | GEO
2017-08-22 | GSE97814 | GEO
2017-08-22 | GSE97813 | GEO
2015-03-30 | GSE63280 | GEO