Transcriptomics

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Identification of MucR regulatory targets


ABSTRACT: The transcriptional regulator MucR was identified as highly attenuated in a mutagenesis screen conducted by this laboratory. MucR has been described as a key regulator of exopolysaccharide synthesis in closely related Rhizobials soil symbionts. The goal of this study was to apply custom Brucella melitensis oligonucleotide microarrays to identify the regulatory targets of MucR. These studies revealed that MucR's regulation of exopolysaccharide synthesis is also conserved in Brucella melitensis and is also a key regulator of iron sequestering/storage and denitrification. Keywords: Microarray comparison of a genetically modified organism compared to wild type.

ORGANISM(S): Brucella melitensis bv. 1 str. 16M Brucella melitensis

PROVIDER: GSE13647 | GEO | 2010/04/23

SECONDARY ACCESSION(S): PRJNA110199

REPOSITORIES: GEO

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