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DHH1/DDX6-like RNA helicases maintain ephemeral half-lives of stress-response mRNAs

ABSTRACT: Gene transcription is counterbalanced by mRNA decay processes that regulate transcript quality and quantity. We show here that the evolutionarily conserved DHH1/DDX6-like RNA HELICASEs of Arabidopsis thaliana control the ephemerality of a subset of cellular mRNAs. These RNA helicases co-localize with key markers of processing bodies and stress granules and contribute to their subcellular dynamics. They function to limit the precocious accumulation and translation of stress-responsive mRNAs associated with autoimmunity and growth inhibition under non-stress conditions. Given the conservation of this RH subfamily, they may control basal levels of conditionally-regulated mRNAs in diverse eukaryotes, accelerating responses without penalty.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE136713 | GEO | 2020/04/29

REPOSITORIES: GEO

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