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Identification of distinct immune subtypes in colorectal cancer based on stroma compartment

ABSTRACT: Tumor environment is of vital importance for the incidence and development of colorectal cancer. In order to decipher tumor environment feature of colorectal cancer and explore the role of its immune context composition in cancer classification, we performed gene expression microarray on microdissection processed stroma compartments of colorectal cancer and adjacent normal tissues. Integrated analysis of our data with public gene expression microarray data of microdissection processed stromal and epithelial tissues of colorectal, we identified three immune subtypes — active immune, active stroma and mixed type. These immune subtypes differed by immune cell infiltration pattern, expression of immune checkpoint inhibitors mutation landscape, extent of mutation burden, extent of copy number burden and prognosis. Together, these results suggested that dividing colorectal cancer characterized by tumor environment is of vital important in predicting patients clinical outcome and help to guide precision and personalized management.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136735 | GEO | 2020/02/03

REPOSITORIES: GEO

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