Genomics

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Mouse ESCs (ES-D3) with Ash2l depletion


ABSTRACT: We showed a novel mechanism in which Ash2l directly binds to super-enhancers of several stemness genes to regulate pluripotency and self-renewal in pluripotent stem cells. Ash2l recruits Oct4/Sox2/Nanog (OSN) to form Ash2l/OSN complex at the super-enhancers of Jarid2, Nanog, Sox2, and Oct4, and further drives enhancer activation, upregulation of stemness genes, and maintains the pluripotent circuitry. Ash2l knockdown abrogates the OSN recruitment to all super-enhancers and further hinders the enhancer activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE136870 | GEO | 2020/01/24

REPOSITORIES: GEO

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