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Proliferation-competent Tcf1+ CD8 T-cells in dysfunctional populations are CD4 T-cell help independent

ABSTRACT: Effector CD8 T-cell responses in chronic infection and cancer are maintained by proliferation competent progenitors, which share features with the progenitors of memory T-cells in acutely resolved infections. Combining classical assessment of population dynamics with single cell RNA-sequencing, we discovered a switch in the need for CD4 help between related populations in acute and chronic infection. While in acute infection memory T-cells but not effector T-cells are CD4 help dependent, we found the opposite in chronic infection. Thus, progenitor cells in chronic infection acquire a level of autonomous function that is not seen among their counterparts in acute infection. Vice versa, the dependece of the effector cells highlight why a functional antigen-specific CD4 T-cell compartment is critical in therapeutic settings.

ORGANISM(S): Mus musculus

PROVIDER: GSE137007 | GEO | 2019/09/11

REPOSITORIES: GEO

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