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Early arthritis CD4+ T cell DNA methylation profiling

ABSTRACT: With a focus on rheumatoid arthritis (RA), we sought new insight into genetic mechanisms of adaptive immune dysregulation to help prioritise molecular pathways for targeting in this and related immune pathologies. Whole genome methylation data from isolated CD4+ T cells of >100 genotyped and phenotyped inflammatory arthritis patients, all of whom were naïve to immunomodulatory treatments, were obtained. Analysis integrated these comprehensive data with GWAS findings across IMDs and other publically available resources.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137593 | GEO | 2019/12/17

REPOSITORIES: GEO

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