The apoA-I induced transcriptome and dependence on MyD88
Ontology highlight
ABSTRACT: Apolipoprotein A-I is well known to play a role in cholesterol efflux, but our studies suggest that apoA-I may also induce proinflammatory signaling. The molecular mechanisms behind apoA-I-mediated proinflammatory signaling have not yet been explored, nor has the link between this signaling and cholesterol efflux. We hypothesize that apoA-I is a novel TLR agonist, signaling through the MyD88 proinflammatory signaling adaptor to induce cytokines. Microarray analysis confirmed that a suite of pro-inflammatory genes are induced by apoA-I with varying dependence upon MyD88, and that MyD88 regulates >6% of the apoA-I-induced transcriptome.
ORGANISM(S): Mus musculus
PROVIDER: GSE13772 | GEO | 2010/06/15
SECONDARY ACCESSION(S): PRJNA110779
REPOSITORIES: GEO
ACCESS DATA