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Targeting KDM4A epigenetically activates tumor cell-intrinsic immunity and overcomes resistance to PD1 blockade in squamous cell carcinoma by inducing DNA replication stress

ABSTRACT: To investigate the mechanisms by which KDM4A knockout ameliorates the invasive growth and metastasis of primary mouse squamous cell carcinoma (SCC), we isolated fresh SCCs from tumor cell-specific KDM4A knockout and control mice, and then did the whole transcriptome analysis using RNA-Seq. Results showed that KDM4A knockout stimulated anti-tumor immunity.

ORGANISM(S): Mus musculus

PROVIDER: GSE137953 | GEO | 2021/03/23

REPOSITORIES: GEO

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KDM4A regulated genes in human squamous carcinoma cells

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KDM4A regulated genes in human squamous carcinoma cells

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