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Cytosolic phospholipase A2 alpha regulates TLR signaling and migration in metastatic 4T1 cells

ABSTRACT: We aimed at characterizing the response to reduced cPLA2α activity in metastatic versus non-metastatic cells. We employed an isogenic murine cell line pair displaying metastatic (4T1) and non-metastatic (67NR) phenotype to investigate the role of cPLA2α on migration. Further, we elucidate the effect of reduced cPLA2α activity on global gene expression in the metastatic cell line We found that cPLA2α inhibition may inhibit metastasis through an anti-migratory effect, possibly involving Toll-like receptor signaling and type I interferons

ORGANISM(S): Mus musculus

PROVIDER: GSE138026 | GEO | 2019/09/26

REPOSITORIES: GEO

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Cytosolic phospholipase A2 alpha regulates TLR signaling and migration in metastatic 4T1 cells

Project description:Cytosolic phospholipase A2 alpha regulates TLR signaling and migration in metastatic 4T1 cells

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Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells.

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