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Consequences of an in utero TCDD exposure on the male reproductive function in 5 postnatal days rat

ABSTRACT: Our project focuses on the effects of an in utero TCDD exposure on the male reproductive function. Keywords: transcriptionnal analysis

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE13812 | GEO | 2010/12/01

SECONDARY ACCESSION(S): PRJNA114597

REPOSITORIES: GEO

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Consequences of an in utero TCDD exposure on the male reproductive function in 28 postnatal days rat

Project description:Our project focuses on the effects of an in utero TCDD exposure on the male reproductive function. Keywords: transcriptionnal analysis

2010-12-01 | GSE13838 | GEO

Consequences of an in utero TCDD exposure on the male reproductive function in 28 postnatal days rat

Project description:Our project focuses on the effects of an in utero TCDD exposure on the male reproductive function. Keywords: transcriptionnal analysis Pregnant rats were given either one oral dose of 2,3-7,8 TCDD (200 ng/kg) or equal volume of vehicule (sesame oil). Male rats were sacrified 28 postnatal days and testes were harvested. RNA were extracted with Rneasy mini kit. A pool of RNA from vehicule group was used as the reference group. Each rat submitted to TCDD was compared to reference group. Four biological replicates were processed in a dye swap experimental plan.

2010-12-01 | E-GEOD-13838 | biostudies-arrayexpress

Consequences of an in utero TCDD exposure on the male reproductive function in 5 postnatal days rat

Project description:Our project focuses on the effects of an in utero TCDD exposure on the male reproductive function. Keywords: transcriptionnal analysis Pregnant rats were given either one oral dose of 2,3-7,8 TCDD (200 ng/kg) or equal volume of vehicule (sesame oil). Male rats were sacrified 5 postnatal days and testes were harvested. RNA were extracted with Rneasy mini kit. A pool of RNA from vehicule group was used as the reference group. Each rat submitted to TCDD was compared to reference group. Four biological replicates were processed in a dye swap experimental plan.

2010-12-01 | E-GEOD-13812 | biostudies-arrayexpress

Consequences of an in utero TCDD exposure on the male reproductive function in 5 and 28 postnatal days rat

Project description:This SuperSeries is composed of the following subset Series: GSE13812: Consequences of an in utero TCDD exposure on the male reproductive function in 5 postnatal days rat GSE13838: Consequences of an in utero TCDD exposure on the male reproductive function in 28 postnatal days rat Refer to individual Series

2010-12-01 | E-GEOD-13839 | biostudies-arrayexpress

Consequences of an in utero TCDD exposure on the male reproductive function in 5 and 28 postnatal days rat

Project description:This SuperSeries is composed of the SubSeries listed below.

2010-12-01 | GSE13839 | GEO

In utero and lactational exposure to TCDD induces disruption of prostate glands and fibrosis in rhesus monkeys

Project description:[Original title] In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces disruption of the prostate glands and fibrosis in rhesus monkeys. We investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on the prostate in rhesus monkey offspring. Dams received 0, 30 or 300 ng/kg TCDD subcutaneously on Day 20 of gestation, and then 5% of the initial dose was injected every 30 days until Day 90 after delivery. The offspring were maintained until reaching sexual maturity, and examined histopathologically. Dose-dependent decreases in the prostate glands and widespread fibrosis were observed in offspring. It is noteworthy that 7 years from the final lactational TCDD exposure, inflammatory cell infiltration and disruption of the prostate glands were also observed. Differential mRNA expression associated with fibrosis, inflammatory response and disruption of cell components were demonstrated by microarray analysis, and up-regulation of TGM4, TGFB1, COL1A1 and MMP2 was confirmed with Real-time PCR. In conclusion, in utero and lactational exposure to TCDD induced dose-proportional prostatic fibrosis, indicating prostatic dysfunction and inducible semen quality reduction in second-generation rhesus monkeys.

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In utero and lactational exposure to TCDD induces disruption of prostate glands and fibrosis in rhesus monkeys

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Transcriptional Profiling of Maternal and Fetal Organs following Rat In Utero TCDD or TCDF Exposure

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In utero and lactational TCDD exacerbates the effects of hormone treatment in a model of lower urinary tract dysfunction

Project description:Targeted proteomics using an inclusion list in a data-dependent acquisition method. Mouse prostates were analyzed to determine the effects of developmental exposure to the dioxin TCDD after hormone treatment

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