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Differential transcriptional responses in human cardiomyocytes

ABSTRACT: We report the application of a pericentriolar material 1 (PCM-1) based cardiomyocyte-specific nuclear isolation protocol on human cardiac tissue to specifically ask what transcriptional changes occur in cardiomyocytes of humans with atrial fibrillation. We performed RNA-sequencing on the cardiomyocyte-specific nuclear RNA and found that there are more differentially dysregulated (1343) than similarly regulated transcripts (99) in the right versus left atria. This study is the first of its kind aimed at understanding the transcriptional changes that occur specifically in the left and right atrial cardiomyocytes of humans with atrial fibrillation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138252 | GEO | 2020/09/11

REPOSITORIES: GEO

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Differential transcriptional responses to cardiomyocyte-specific Notch activation in right versus left atria of murine cardiac tissue

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