Genomics

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The Set1 N-terminal domain and Swd2 interact with the RNA polymerase II CTD to recruit COMPASS


ABSTRACT: Methylation of histone H3 lysine 4 (H3K4) by the Set1/COMPASS complex is coupled with active transcription, and this modification is important for regulating gene expression. Set1/COMPASS associates with the RNA polymerase II (RNApII) C-terminal domain (CTD) to establish proper levels and distribution of H3K4 methylations.To ask how the Set1-RNApII CTD binding affects the occupancy and overall level of H3K4 methylations, ChIP-Seq was pefromed in cells transformed with full length or N-terminal truncated Set1. Our results indicate that Set1-RNApII CTD interaction is necessary for maintaining H3K4 methylations throughout the genes.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE138281 | GEO | 2019/10/02

REPOSITORIES: GEO

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