DNA methylation and gene expression changes during acquired resistance to ALK inhibitors (scRNA-seq)
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ABSTRACT: To identify novel mechanisms of acquired resistance to ALK inhibitors, we established in vitro models of acquired resistance to ceritinib using H3122 cell. In this study, we examined genome-wide DNA methylation changes during acquired resistance to ceritinib. We also examined the heterogeneity of parental and resistant cells using single cell RNA--seq.
ORGANISM(S): Homo sapiens
PROVIDER: GSE139386 | GEO | 2022/09/20
REPOSITORIES: GEO
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