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Effect of L1CAM Knockout on Gene Expression in the Cerebellum

ABSTRACT: Cerebellum from post-natal day 11 L1 knockout mice on the 129Sv background were compared to wild type littermates. The original goal of the study was to determine if there was compensation from other L1 family members or alterations in cell survival or apoptosis. Interestingly no major changes were detected in those families or pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE13984 | GEO | 2008/12/17

SECONDARY ACCESSION(S): PRJNA110245

REPOSITORIES: GEO

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Effect of L1CAM Knockout on Gene Expression in the Cerebellum

Project description:Cerebellum from post-natal day 11 L1 knockout mice on the 129Sv background were compared to wild type littermates. The original goal of the study was to determine if there was compensation from other L1 family members or alterations in cell survival or apoptosis. Interestingly no major changes were detected in those families or pathways. The microarray experiment was conducted by extracting total RNA from the cerebellums of three postnatal day 11 congenic 129Sv L1 knock outs and three of their wild type siblings utilizing Qiagen's RNeasy Mini kit (# 74104). Therefore, each genotype, L1KO and wildtype, had three replicates. Samples were processed at the Case Western Reserve University Cancer Center Gene Expression Array Core Facility and hybridized to Affymetrix Murine Genome U74AV2 gene chips.

2008-12-17 | E-GEOD-13984 | biostudies-arrayexpress

polyA mRNA RNA-seq from cerebellum (ENCSR000BZM)

Project description:The libraries contained in this experiment come from adult 8 week cerebellum tissue from mixed sex littermates in mouse strain C57BL/6J. They are stranded PE101 Illumina Hi-Seq RNA-Seq libraries from rRNA-depleted Poly-A+ RNA > 200 nucleotides in size. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

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Target genes of thyroid hormone in cerebellum neurons

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mRNASeq of kidney, liver, and cerebellum of P195A/p150- and P195A/p150+ mice

Project description:The goal of this experiement was to determine what transcriptional differences there are between P195A/p150- (sick) and P195A/p150+ (healthy) mice. Kidney, Liver, and Cerebellum were the most clearly affected on histology and qPCR for IFN. We found an IFN signature and ISR signature were both upregulated in P195A/p150- mice as compared to P195A/p150+ littermates.

2021-08-26 | GSE162583 | GEO

L1CAM overexpression in mouse lung endothelial cells (lECs)

2014-10-21 | GSE45859 | GEO

L1CAM overexpression in mouse lung endothelial cells (lECs)

Project description:In an attempt to elucidate the molecular mechanisms underlying the multiple roles of L1 in endothelium, we checked whether manipulating its expression affected the transcriptome of lECs. To this purpose, we compared the gene expression profiles of L1-overexpressing and control lECs by Affymetrix, which revealed a remarkable effect of L1 overexpression on lECs transcriptome. Mouse lung-derived EC (lECs), kindly provided by E. Dejana (Milan, Italy), were stably transfected with a pcDNA3.1/Hygro(-) vector containing mouse LICAM full length or with and empty pcDNA3.1/Hygro(-) vector as control. Three independent experimental replicates were performed.

2014-10-21 | E-GEOD-45859 | biostudies-arrayexpress

Cerebellum Alzheimer's Disease

Project description:Ion channel splice array data from cerebellum brain tissue samples collected from Alzheimer's disease patients. Temporal cortex (Alzheimer's disease affected brain tissue structure) and cerebellum (Alzheimer's disease unaffected brain tissue structure) samples from control subjects were compared to temporal cortex and cerebellum of patients with Alzheimer's disease.

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Transcriptome of Ts1Cje and euploids cerebellum

Project description:Transcriptome analysis of Ts1Cje (mouse model of Down syndrome) and euploids murine cerebellum during postnatal development Keywords = Down syndrome Keywords = Chromosome 21 Keywords = Transcriptome Keywords = Microarray Keywords = Cerebellum Keywords = Development Keywords: other

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Cerebellum Alzheimer's Disease

Project description:Ion channel splice array data from cerebellum brain tissue samples collected from Alzheimer's disease patients. Keywords: disease associated splicing changes

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Target genes of thyroid hormone in cerebellum neurons

Project description:Cerebellar post-natal development is particularly sensitive to thyroid hormone and low levels of thyroid hormone (hypothyroidism) result in permanent defects in cerebellar architecture and function. All cell types of the cerebellum are affected, but the main sign of hypothyroidism in mice is the persistence of the external granular layer, composed of mitotic neuronal precursors at P21. To make the genetic link between thyroid hormone and cerebellar development, we sought to identify new thyroid hormone target genes, in particular in granule cells which represent the vast majority of cerebellar cells. Primary cultures of cerebellar neurons were made by dissociation of cerebella from newborn wild-type mice. These cells were plated 48 hours in serum-free medium to avoid invasion of the culture by glial cells. In order to include a kinetic and a maximum number of target genes, several cultures were either treated or left untreated as controls for 6 hours (T1), 16 hours (T2), 24 hours (T3) or 48 hours (T4) and results were pairwise compared for each time point.

2012-03-29 | E-GEOD-24793 | biostudies-arrayexpress

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