Transcriptome profiling by RNA-sequencing of the AML cell lines UCSD-AML1 and ELF-153.
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ABSTRACT: DNMT inhibitors (DNMTi) are finally approved for AML/MDS, also based on their activity in patients with high-risk cytogenetics (often monosomal karyotype) such as -5/del(5q) or -7/del(7q), often - but not always - harboring TP53-mutations. Several studies provided evidence for aberrant hypermethylation/silencing on monoallelic gene loci, including tumor suppressor genes. We hypothesized that transcriptional repression on monosomal gene loci may be preferentially reversed by DNMTi. Using an unbiased RNA-seq approach we aimed to identify preferentially regulated genes in cells monoallelic for chromosome 7q.
ORGANISM(S): Homo sapiens
PROVIDER: GSE140347 | GEO | 2021/03/09
REPOSITORIES: GEO
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