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SAM68 is a splicing regulator in triple negative breast cancer

ABSTRACT: SAM68 is an RNA binding protein frequently up-regulated in several human cancers and its oncogenic activity has often been associated with its splicing activity. Nevertheless, the genome-wide impact of SAM68 on the transcriptome of cancer cells is still unknown. Herein, by high-throughput RNA sequencing analysis of MDA-MB-231 SAM68-silenced cells, we uncover an extensive modulation of triple-negative breast cancer cell transcriptome by this splicing factor.

ORGANISM(S): Homo sapiens

PROVIDER: GSE140754 | GEO | 2022/04/04

REPOSITORIES: GEO

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NEK2 regulates triple negative breast cancer transcriptome.

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SAM68 promotes Lung adenocarcinoma tumorigenesis by regulating cancer metabolic conversion through alternative splicing

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SAM68 is a splicing regulator in triple negative breast cancer

Project description:SAM68 is a splicing regulator in triple negative breast cancer

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SAM68-specific splicing is required for proper selection of alternative 3'UTR isoforms in the nervous system

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