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Platinum chemotherapy induces diverse evolutionary trajectories in high grade serous ovarian cancer

ABSTRACT: Cisplatin- and carboplatin-resistant high-grade serous ovarian cancer (HGSC) cells were generated and new lines were created from single cell clones. All cells were derived from a common ancestral line, Ovcar4. RNA sequencing was performed to examine transcriptional changes related to acquisition of platinum resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141630 | GEO | 2022/08/01

REPOSITORIES: GEO

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