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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE141640 | GEO | 2024/09/10

REPOSITORIES: GEO

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

Project description:IFN-I suppresses the number of pre-pDCs and pDC development after infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the chromatin landscapes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV) after IFN-I receptor blockade with neutralizing antibodies.

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [RNA-seq]

Project description:Dendritic cell (DC) subsets are critical for immune responses, but their development from progenitors and maturation are often altered during infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the transcriptomes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV).

2024-09-10 | GSE141638 | GEO

Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq]

Project description:Dendritic cell (DC) subsets are critical for immune responses, but their development from progenitors and maturation are often altered during infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the Chromatin landscapes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV).

2024-09-10 | GSE141637 | GEO

Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

Project description:Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq]

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

Project description:Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

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Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.

Project description:Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs.

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Project description:In mice, two restricted dendritic cell (DC) progenitors, macrophage/dendritic progenitors (MDPs) and common dendritic progenitors (CDPs), demonstrate increasing commitment to the DC lineage, as they sequentially lose granulocyte and monocyte potential, respectively. Identifying these progenitors has enabled us to understand the role of DCs and monocytes in immunity and tolerance in mice. In humans, however, restricted monocyte and DC progenitors remain unknown. Progress in studying human DC development has been hampered by lack of an in vitro culture system that recapitulates in vivo DC hematopoiesis. Here we report a culture system that supports development of CD34(+) hematopoietic stem cell progenitors into the three major human DC subsets, monocytes, granulocytes, and NK and B cells. Using this culture system, we defined the pathway for human DC development and revealed the sequential origin of human DCs from increasingly restricted progenitors: a human granulocyte-monocyte-DC progenitor (hGMDP) that develops into a human monocyte-dendritic progenitor (hMDP), which in turn develops into monocytes, and a human CDP (hCDP) that is restricted to produce the three major DC subsets. The phenotype of the DC progenitors partially overlaps with granulocyte-macrophage progenitors (GMPs). These progenitors reside in human cord blood and bone marrow but not in the blood or lymphoid tissues.

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