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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE141640 | GEO | 2024/09/10

REPOSITORIES: GEO

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

Project description:IFN-I suppresses the number of pre-pDCs and pDC development after infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the chromatin landscapes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV) after IFN-I receptor blockade with neutralizing antibodies.

2024-09-10 | GSE190437 | GEO

Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [RNA-seq]

Project description:Dendritic cell (DC) subsets are critical for immune responses, but their development from progenitors and maturation are often altered during infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the transcriptomes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV).

2024-09-10 | GSE141638 | GEO

Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq]

Project description:Dendritic cell (DC) subsets are critical for immune responses, but their development from progenitors and maturation are often altered during infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the Chromatin landscapes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV).

2024-09-10 | GSE141637 | GEO

Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

Project description:Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq]

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

Project description:Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [RNA-seq]

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Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.

Project description:Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs.

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Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss.

Project description:Bone marrow fat is implicated in metabolism, bone health and haematological diseases. Thus, this study aims to analyse the impact of moderate weight loss on bone marrow fat content (BMFC) in obese, healthy individuals. Data of the HELENA-Trial (Healthy nutrition and energy restriction as cancer prevention strategies: a randomized controlled intervention trial), a randomized controlled trial (RCT) among 137 non-smoking, overweight or obese participants, were analysed to quantify the Magnetic Resonance Imaging (MRI)-derived BMFC at baseline, after a 12-week dietary intervention phase, and after a 50-week follow-up. The study cohort was classified into quartiles based on changes in body weight between baseline and week 12. Changes in BMFC in respect of weight loss were analysed by linear mixed models. Spearman's coefficients were used to assess correlations between anthropometric parameters, blood biochemical markers, blood cells and BMFC. Relative changes in BMFC from baseline to week 12 were 0.0 ± 0.2%, -3.2 ± 0.1%, -6.1 ± 0.2% and -11.5 ± 0.6% for Q1 to Q4. Across all four quartiles and for the two-group comparison, Q1 versus Q4, there was a significant difference (p < 0.05) for changes in BMFC. BMFC was not associated with blood cell counts and showed only weaker correlations (<0.3) with metabolic biomarkers. Weight loss is associated with a decrease of BMFC. However, BMFC showed no stronger associations with inflammatory and metabolic biomarkers.

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