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Shear stress-induced long non-coding RNA, NIMBUSS, is required for the KLF2-mediated gene expression profile associated with vascular homeostasis I

ABSTRACT: The endothelial cell (EC) response to shear stress is partly mediated by the transcription factor KLF2, which is preferentially activated by laminar flow and promotes an atheroprotective phenotype. The up-regulation of KLF2 elicits anti-inflammmatory, anti-coagulant, and pro-vasodilatory processes. To investigate the function of the flow-induced long non-coding RNA (lncRNA) NIMBUSS, we performed loss-of-function studies using siRNA for NIMBUSS in ECs overexpressing KLF2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142372 | GEO | 2024/12/01

REPOSITORIES: GEO

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Transcriptional adaptations of HUVECs exposed to high and low fluid shear stress

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2011-02-01 | E-GEOD-23289 | biostudies-arrayexpress

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2018-03-15 | E-MTAB-6640 | biostudies-arrayexpress

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2019-07-25 | MTBLS739 | MetaboLights

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