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Tracking epigenetic changes during human leukemogenesis

ABSTRACT: We have developed a human model leukemia system where healthy cord blood (CB) cells from single donors are used to generate dozens of human leukemias driven by KMT2A fusions. These models have been used for the study of the stepwise changes in donor CB cells as they undergo leukemic transformation driven by the KMT2A-MLLT3 (KM3) fusion gene. We specifically studied the epigenetic changes that occur in this specific AML subgroup through ChIP-seq of histone modifications and ATAC-seq and DNA methylation through Methyl-Seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142579 | GEO | 2020/07/01

REPOSITORIES: GEO

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