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Expression data from conventional osteosarcoma compared to primary non-neoplastic osteoblast cells

ABSTRACT: In osteosarcoma patients, the development of metastases, often to the lungs, is the most frequent cause of death. To improve this situation, a deeper understanding of the molecular mechanisms governing osteosarcoma development and dissemination and the identification of novel drug targets for an improved treatment are needed. Towards this aim, we characterized osteosarcoma tissue samples compared to primary osteoblast cells using Affymetrix HG U133A microarrays.

ORGANISM(S): Homo sapiens

PROVIDER: GSE14359 | GEO | 2010/06/30

SECONDARY ACCESSION(S): PRJNA111391

REPOSITORIES: GEO

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Expression data from conventional osteosarcoma compared to primary non-neoplastic osteoblast cells

Project description:In osteosarcoma patients, the development of metastases, often to the lungs, is the most frequent cause of death. To improve this situation, a deeper understanding of the molecular mechanisms governing osteosarcoma development and dissemination and the identification of novel drug targets for an improved treatment are needed. Towards this aim, we characterized osteosarcoma tissue samples compared to primary osteoblast cells using Affymetrix HG U133A microarrays. mRNA from 5 frozen conventional osteosarcoma and 4 osteosarcoma lung metastases tumor samples and mRNA from fresh primary osteoblast cells were extracted and hybridized to HG U133A microarrays.

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