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Molecular comparison of an LSC population and a more differentiated cell population

ABSTRACT: We identified 2 phenotyically and functionally distinct populations in our AML-iPSC line upon hematopoieyic differentiation. One population adheres (iLSCs = samples A) and one stays in suspension (iBlasts = samples S). The iLSCs are phenotyically and functionally leukemia stem cells and the iBlasts are more differentiated cells. We identified the RUNX1 motif as one of the top TF motfs enriched in more accessible peaks in iLSCs compared to iBlasts. Here we perform RUNX1 CHIP-seq on iLSCs (=A) and iBlasts (=S).

ORGANISM(S): Homo sapiens

PROVIDER: GSE143679 | GEO | 2020/04/30

REPOSITORIES: GEO

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