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RNA-Seq of mouse CD69+ regulatory T cells (Treg) in venous blot clots

ABSTRACT: Transcriptional profiling shows that Treg in venous thrombi take on a repair Treg profile and produce the matricellular protein SPARC

ORGANISM(S): Mus musculus

PROVIDER: GSE144042 | GEO | 2023/01/06

REPOSITORIES: GEO

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Specialized regulatory T cells control venous blood clot resolution through SPARC

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RNA-Seq of mouse CD69+ regulatory T cells (Treg) in venous blot clots

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Specialized regulatory T cells control venous blood clot resolution through SPARC

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Genome-wide analysis of SPARC(secreted protein acidic and rich in cysteine)-responsive gene expression in HTR-8/SVneo cells

Project description:SPARC is a matricellular glycoprotein that plays critical roles in the pathologies associated with obesity and diabetes, as well as tumorigenesis. The objective of this study was to investigate the role of SPARC in the process of trophoblast invasion which shares many similarities with tumor cells invasion. Our results reveals that hormones, cell adhesion molecules, ECM molecules, growth factors and cytokines all are mediated by SPARC in EVT invasion. HTR-8/SVneo cells were transfected with SPARC siRNA or a 25-nucleotide universal negative control siRNA using Lipofectamine 2000 according to the manufacturer’s protocol. Seventy-two hours after transfection, cells were harvested and RNA was isolated using standard procedures.

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A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in cancer

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The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging

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Cognate antigen recognition defines intestinal Treg specialization and stability

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