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Specialized regulatory T cells control venous blood clot resolution through SPARC

ABSTRACT: The cells and mechanisms involved in blood clot resorption are only partially known. Regulatory T cells (Treg) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. The clot Treg population is heterogeneous and contains a population of Treg that forms the matricellular acid- and cysteine-rich protein (SPARC). SPARC induces MMP activity in monocytes and SPARC+ Treg are required for clot resorption.

ORGANISM(S): Mus musculus

PROVIDER: GSE155444 | GEO | 2023/06/01

REPOSITORIES: GEO

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| PRJNA649772 | ENA

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