Mechanisms of immune evasion in P. falciparum malaria revealed by integrative gene expression profiling [RNA-seq]
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ABSTRACT: We performed a genome-wide profiling of miRNAs and mRNA, DNA sequencing of human whole blood sample to identify miRNAs responsive to P.falciparum (P.f) infection and/or associated with parasite load. We identified a set of 72 miRNAs that are positively or negatively associated with parasitemia. We also performed expression quantitative trait loci of miRNAs(miR-eQTL) of P.f infected individuals. The miR-eQTL dataset allowed us to determine relevant genetic variant responsible for miRNAs expression differences between P.f infected individuals and find novel malaria-associated miRNAs
ORGANISM(S): Homo sapiens
PROVIDER: GSE144476 | GEO | 2020/09/05
REPOSITORIES: GEO
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