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RNA sequencing analysis of WT- and Tet2-/-G17VRHOA-CD4 splenocytes

ABSTRACT: Angioimmunoblastic T-cell lymphoma, a subtype of T-cell lymphoma, is a disease with relative poor outcome. Genetic analysis in human samples showed the co-existence of common mutations in TET2 and RHOA genes. We have made a mouse model resembling the genetic lesions in human AITL. Our mice developed AITL-like lymphoma after 40 weeks old. We analyzed the expression of transcriptomes in WT- and Tet2-/-G17VRHOA-CD4 splenocytes to find out the underlying pathogenesis mechanism of AITL.

ORGANISM(S): Mus musculus

PROVIDER: GSE144654 | GEO | 2020/02/04

REPOSITORIES: GEO

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