Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Increased fitness of pancreatic cancer cells Adapted to nutrient deprivation

ABSTRACT: Pancreatic cancer cells adapted to low nutrient conditions share common transcriptional programs that correlate with alterations in open chromatin states.

ORGANISM(S): Homo sapiens

PROVIDER: GSE144833 | GEO | 2021/02/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Shared Molecules

Only show the datasets with similarity scores above: 0.5

Threshold

0.5

Similar Datasets

Increased fitness of pancreatic cancer cells Adapted to nutrient deprivation

Project description:Increased fitness of pancreatic cancer cells Adapted to nutrient deprivation

| PRJNA605101 | ENA

Transcriptomic reprogramming of Ethanol adapted vs Ethanol non adapted culture

2009-09-01 | GSE15321 | GEO

Transcriptional profiling of mouse pancreatic tumor cells under nutrient and oxygen deprivation condition

Project description:Transcriptional profiling showed that adaptation to nutrient and oxygen deprivation condition is associated with widespread transcriptional reprogramming resulting in the induction of glycolysis and autophagy and repression of the TCA cycle and biosynthesis

2021-08-24 | GSE176075 | GEO

Transcriptional profiling of human pancreatic tumor cells under nutrient and oxygen deprivation condition

2021-08-24 | GSE176074 | GEO

Transcriptomic reprogramming of Ethanol adapted vs Ethanol non adapted culture

Project description:We have previously shown that fed-batch processes with the longest uncoupling phase (ethanol adapted) were characterized by induction of storage carbohydrates, a metabolic event typical of yeast cells experiencing nutrient limitation, at the onset of this phase, whereas this metabolic event was not seen in processes with a short uncoupling phase (ethanol non adapted culture). Taken together, our results suggested that reproducible high bioethanol performance in aerated fed-batch process may be linked to the ability of yeast cells to impede ethanol toxicity by triggering a metabolic remodelling reminiscent to that of cells entering a quiescent G0/G1 state. The aim of this study was to search for genes implicated in the induction an ethanol adapted culture vs ethanol non-adapted culture. We measure the changes in the gene expression of Ethanol adapted culture (Test : fermentation I in ref 17005001[PMID]) and Ethanol non-adapted (reference : Fermentation II in ref 17005001[PMID]) at the same ethanol concentration of 60 g/l and the same growth rate of the cells (0,14 h-1 :Test) and (0,13 h-1 : reference) to reduce the risk of observing secondary effects due to growth and ethanol stress. For each sample, total RNAs from one yeast culture (no biological replicate) were extracted four times (technical replicates -extract). For labelling, we employed a dye-switch (dCTP-Cy3 and dCTP-Cy5) repeated 2 times and hybridized cDNA on four independent microarrays, given rise to eight data value per gene (each gene is duplicate on the slide).

2009-08-31 | E-GEOD-15321 | biostudies-arrayexpress

Molecular mechanism of mice embryonic diapause induction by nutrient deprivation

Project description:To thoroughly characterize the diapaused blastocyst induced by ovariectomy, maternal starvation, and nutrient deprivation, we executed RNA-sequencing analyses for ND blastocysts at E4.5, DIA, Sta, K-PC, and K+0.02 blastocysts at E5.5.

2022-12-18 | GSE220804 | GEO

Transcriptional profiling of pancreatic tumor cells under nutrient and oxygen deprivation condition

Project description:Transcriptional profiling of pancreatic tumor cells under nutrient and oxygen deprivation condition

| PRJNA734796 | ENA

Transcriptomic profiling of human HAP1 cells before and after nutrient deprivation

Project description:Autophagy is a lysosomal degradation pathway critical for maintaining cellular homeostasis and viability, and is predominantly regarded as a rapid and dynamic cytoplasmic process. To improve our understanding of the transcriptional and epigenetic events associated with autophagy, we performed genome-wide transcriptomic and epigenomic profiling after nutrient deprivation in human wildtype and autophagy-deficient cells. We observed that nutrient deprivation leads to the transcriptional induction of numerous autophagy-associated genes. These transcriptional changes are reflected at the epigenetic level (H3K4me3, H3K27ac, and H3K56ac) and are independent of autophagic flux.

2018-09-28 | GSE107600 | GEO

Epigenetic profiling of human HAP1 cells before and after nutrient deprivation

2018-09-28 | GSE107599 | GEO

Human HAP1 cells before and after nutrient deprivation

Project description:Human HAP1 cells before and after nutrient deprivation

| PRJNA420678 | ENA