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Next-Generation Sequencing Analysis of Wild Type and Rfx1-/- or Rfx2-/- or Rfx3-/- Mouse Ependymal Cells

ABSTRACT: Purpose: This study was carried out to determine the consequences of inactivating either Rfx1, or Rfx2 or Rfx3 on gene expression during differentiation of mouse multiciliated ependymal cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE145323 | GEO | 2020/07/13

REPOSITORIES: GEO

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Project description:Purpose: This study was carried out to determine RFX1 or RFX2 or RFX3 binding sites in nuclei of multiciliated ependymal cells. Methods: DNA was extracted from ependymal cell cultures. ChIP-sequencing was used to determine the binding sites of RFX1 , RFX2 or RFX3.

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Coordinated genomic control of ciliogenesis and cell movement by Rfx2

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