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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE145341 | GEO | 2020/02/15

REPOSITORIES: GEO

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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis.

Project description:Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are still understudied. Publicly available DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to test if 19p loss is significantly over-represented in children and adolescents with neuroblastoma. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined by meta-analysis and corrected by Bonferroni's method. In both sets, 19p loss was associated with older age at diagnosis. Particularly, the lowest age group significantly associated with 19p loss (discovery set: 20%; validation set: 35%) was 6 years. The 19p loss correlated with inferior overall survival in patients over 6 years of age. Relevant tumor suppressor genes (KEAP1, DNM2, SMARCA4, SLC44A2 and CDKN2D) and microRNAs (miR-181c, miR-27a, and mirR-199a-1) are located in the genomic region involved in 19p loss. Downregulation of DNM2, SLC44A2 and CDKN2D was associated with poor patient outcome and older age. Among the recurrent NB chromosomal aberrations, only 1q gain was enriched in patients older than 6, and its presence was mutually exclusive with respect to 19p loss. Our data demonstrate that 19p loss is a genomic biomarker of NB diagnosed in older children that can predict clinical outcome.

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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)

Project description:Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. In both sets, the lowest age group significantly associated with 19p loss (discovery set: 20%; validation set: 35%) was 6 years. The 19p loss was considered to be a significant marker for overall survival in patients over 6 years of age. Relevant tumor suppressor genes (KEAP1, DNM2, SMARCA4, SLC44A2 and CDKN2D) and microRNAs (miR-181c, miR-27a, and mirR-199a-1) were in 19p loss. Down-regulation of DNM2, SLC44A2 and CDKN2D associated with poor patient outcome and older age. Among the recurrent NB chromosomal aberrations, only 1q gain was enriched in patients older than 6 years and was mutually exclusive respect to 19p loss. Our data demonstrate that 19p loss is a genomic biomarker of NBs diagnosed in older children that can predict clinical outcome.

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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-030587)

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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-014950)

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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 1)

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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 2)

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19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

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