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Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates

ABSTRACT: We applied chromatin accessibility and single cell transcriptome analyses to explore the emergence of heterogeneity and underlying gene-regulatory mechanisms during early gastrulation in Xenopus. TF activity was inferred by integrating chromatin accessibility and single cell transcriptomics. Our results show that combinatorial activity of zygotically expressed transcription factors acts on maternally-regulated accessible chromatin to induce organizer gene expression.

ORGANISM(S): Xenopus tropicalis

PROVIDER: GSE145619 | GEO | 2020/12/18

REPOSITORIES: GEO

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