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Intestinal epithelial GR in the regulation of intestinal inflammation and colon cancer

ABSTRACT: The goal of this project is to investigate the role of glucocorticoids and their receptor, glucocorticoid receptor (GR), in intestinal stress response and tissue homeostasis. Using a mouse model with specific deletion of GR in intestinal epithelium (GR iKO mice), we recently discovered that intestinal epithelial GR deficiency deteriorates acute colitis while reducing chronic inflammation-associated colon cancer formation in mice. To understand the molecular mechanisms underlying these phenotypes, we examined colonic transcriptomes of Flox control and GR iKO mice treated with or without dextran sulfate sodium (DSS) for 7 days by microarray analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE146048 | GEO | 2021/11/15

REPOSITORIES: GEO

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