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Knocking down CAVIN1 in WPMY-1 normal prostate stromal cells

ABSTRACT: Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins (CAV) and caveolae-associated protein 1 (CAVIN1). Genetic alterations of CAV1N1 and CAV1 modify lipid metabolism and underpin lipodystrophy syndromes. Lipids contribute to tumorigenesis by providing fuel to cancer metabolism and supporting growth and signaling. Tumor stroma supports tumor proliferation, invasion and metastasis but how stromal lipids influence these processes remain to be defined. Here we show that stromal CAVIN1 regulates lipid abundance in the prostate cancer microenvironment and suppresses metastasis. We show that depletion of CAVIN1 in prostate stromal cells markedly reduces their lipid droplet accumulation and increases inflammation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146229 | GEO | 2022/01/19

REPOSITORIES: GEO

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Knocking down CAVIN1 in WPMY-1 normal prostate stromal cells

Project description:Knocking down CAVIN1 in WPMY-1 normal prostate stromal cells

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