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Characterization of Alveolar macrophage subsets infected by Cryptococcus neoformans [ATAC-seq]

ABSTRACT: We examined two subpopulations of alveolar macrophages differentiated by CXCL2 expression stimulated by Cryptococcus neoformans. The two subpopulations have distinct mRNA expression pattern indicating the heterogenity within alveolar macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE146234 | GEO | 2020/06/08

REPOSITORIES: GEO

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Characterization of Alveolar macrophage subsets infected by Cryptococcus neoformans

Project description:We examined four subsets of alveolar macrophages differentiated by CXCL2 expression and FLT3 fate mapping induced by Cryptococcus neoformans infection. These four subpopulations have distinct mRNA expression pattern indicating the heterogenity within alveolar macrophages.

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Arginase 1 expression by macrophages promotes Cryptococcus neoformans proliferation and invasion into brain microvascular endothelial cells.

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