Methylation profiling

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Early epigenetic changes precede genetic alterations and drive hepatocarcinogenesis


ABSTRACT: genome-wide methylome and transcriptome profiling of cirrhotic liver, low- and high-grade dysplastic lesions, eHCC and pHCC synchronouCLy detected in HCC patients with chronic hepatitis B infection. Identification of molecular epi-drivers by integrative analyses and validation in two independent cohorts comprising 933 HCC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146286 | GEO | 2021/03/01

REPOSITORIES: GEO

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