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Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

ABSTRACT: We found that concomitant deletion of Trp53 and overexpression of c-MET (c-MET/sgp53) in the mouse liver led to HCC formation in vivo. Subsequently, a stably passaged cell line derived from a c-MET/sgp53 HCC were generated. We then performed gene expression profiling analysis using data obtained from RNA-seq of the c-MET/sgp53 HCC cell line. Wild-type FVB/N mouse liver were used as control.

ORGANISM(S): Mus musculus

PROVIDER: GSE229764 | GEO | 2023/07/30

REPOSITORIES: GEO

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