Transcriptomics

Dataset Information

0

Deficiency of STING-signaling leads to neurogenic abnormalities and Autistic-Like Behaviors in the embryonic cortex [single-cell RNA-seq]


ABSTRACT: Purpose: To gain futher insight into how STING causes abnormal cortical development in mice ,single cell RNA-seq was used to analyze the cell type changes resulting from the cerebral cortices of P0 STING conditional knock out mice and littermate wild-type. Methods: Single cell isolation was prepared from P0 telencephalic tissue of wild-type(WT) and STINGf/f;Nestin-Cre mice. The fragmented cDNAs containing barcode and UMI sequences was built the library . Agilent 2100 Bioanalyze was used to quality controlled and quantified.Single cell RNA-sequencing analysis was used by the Illumina HiSeq 2500 platform in Annoroad Genomics Results: Clustering and labeling of these cells visualized on a t-SNE plot between the wild-type(WT) and STINGf/f;Nestin-Cre mice brain cortex Conclusions: Single cell RNA-seq data would provide a overall understanding of how STING gene influences cortical development in mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE146456 | GEO | 2020/03/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-03-06 | GSE146455 | GEO
2020-02-26 | GSE145934 | GEO
2021-01-26 | GSE165440 | GEO
2023-11-13 | GSE247326 | GEO
2020-02-13 | GSE145169 | GEO
2023-03-25 | GSE227955 | GEO
2024-11-20 | GSE247448 | GEO
2024-07-16 | GSE271827 | GEO
2023-02-03 | GSE202929 | GEO
2014-04-30 | E-GEOD-42369 | biostudies-arrayexpress