Transcriptomics

Dataset Information

0

Differences in transcription in Angelman syndrome and control person iPSC-derived neurons


ABSTRACT: Angelman syndrome is caused by loss of funtional ubiquitin E3 ligase UBE3A and results in severe deley in cognitive and motor development. In neurons, UBE3A locates to the synapse and to the nucleus. Loss of nuclear UBE3A results in development of Angelman syndrome like symptoms in mice. UBE3A can function as transcriptional coactivator of steroid hormone receptors, but the entire function of UBE3A in the nucleus is still not clear. So we wanted to study differences in the transcriptome in neurons differentiated from iPSCs that were derived from patients with Angleman syndrome and normal controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146640 | GEO | 2020/12/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-08-18 | GSE120225 | GEO
2021-08-12 | MSV000087972 | MassIVE
2021-04-01 | GSE160747 | GEO
2020-03-01 | GSE137217 | GEO
2014-10-09 | E-GEOD-32563 | biostudies-arrayexpress
2024-05-09 | PXD048963 | Pride
2020-09-28 | PXD020602 | Pride
2022-12-23 | GSE221378 | GEO
2018-12-15 | MSV000083239 | MassIVE
2014-10-09 | GSE32563 | GEO