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HAP1 is an in vivo UBE3A Target that Augments Autophagy in a Mouse Model of Angelman Syndrome

ABSTRACT: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by maternal mutation and paternal imprinting of the gene encoding UBE3A, an E3 ubiquitin ligase. Although several potential target proteins of UBE3A have been reported, how these proteins regulate neuronal development remains unclear. We performed a large-scale quantitative proteomic analysis using stable-isotope labeling of amino acids in mammals (SILAM) on mice with maternal Ube3a mutation.

INSTRUMENT(S): Q-Exactive( Thermo fisher)

ORGANISM(S): Mus Musculus

SUBMITTER: Lujian Liao

PROVIDER: MSV000083239 | MassIVE | Sat Dec 15 18:40:00 GMT 2018

SECONDARY ACCESSION(S): PXD012075

REPOSITORIES: MassIVE

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