Transcriptomics

Dataset Information

0

Advanced genomics identifies growth effectors for proteotoxic ER stress recovery in Arabidopsis thaliana


ABSTRACT: Adverse environmental and pathophysiological situations can overwhelm the biosynthetic capacity of the endoplasmic reticulum (ER), igniting a potentially lethal condition known as ER stress. ER stress results in growth reduction and the activation of a conserved cytoprotective signaling cascade, the unfolded protein response (UPR), to mitigate ER stress. As ER stress subsides, growth is resumed; however, despite a pivotal role of the UPR in growth restoration, the underlying mechanisms are yet unknown. To discover these, we undertook a genomics approach and mined the gene reprogramming roles of the two critical and conserved UPR modulators, basic leucine zipper28 (bZIP28) and bZIP60 in ER stress resolution. Through a coexpression-based network modeling and experimental validation, we identified key responsive genes acting downstream of the UPR bZIP-transcription factors (bZIP-TF), and demonstrated their roles in organ growth during recovery from ER stress. Our analyses have also set up a novel pipeline for functional gene discovery in ER stress resolution with broad applicability across multicellular eukaryotes.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE146723 | GEO | 2021/12/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-09-30 | GSE185109 | GEO
2015-05-12 | GSE68718 | GEO
2015-05-12 | E-GEOD-68718 | biostudies-arrayexpress
2018-03-07 | GSE100371 | GEO
2016-01-15 | E-GEOD-70208 | biostudies-arrayexpress
2016-10-11 | PXD003961 | Pride
2012-01-01 | GSE30628 | GEO
2012-01-01 | E-GEOD-30628 | biostudies-arrayexpress
2024-09-02 | BIOMD0000000446 | BioModels
2021-02-17 | GSE146841 | GEO