Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Microarray analysis of mRNA and long noncoding RNA expression profiles between multiple myeloma patients and control

ABSTRACT: To further investigate the differential expression gene of multiple myeloma.Three multiple myeloma samples and three normal samples were used for microarray.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146757 | GEO | 2023/10/06

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Multiple myeloma

Project description:Multiple myeloma

| PRJNA515992 | ENA

Microarray analysis of mRNA and long noncoding RNA expression profiles between multiple myeloma patients and control

Project description:Microarray analysis of mRNA and long noncoding RNA expression profiles between multiple myeloma patients and control

| PRJNA611816 | ENA

Multiple myeloma patients and control

Project description:Multiple myeloma patients and control

| PRJNA668106 | ENA

Multiple Myeloma cells

Project description:Multiple Myeloma cells

| PRJNA800411 | ENA

miRNA expression profiles of multiple myeloma

Project description:To further investigate the differential expression miRNA of multiple myeloma, three multiple myeloma samples and three normal samples were used for miRNA sequencing.

2023-10-06 | GSE159231 | GEO

H3K27ac ChIP-seq for primary multiple myeloma patients’ samples (MM1-MM10)

Project description:ChIP-seq analysis was performed in primary Multiple Myeloma patients’ samples to analyze acetylation of histone H3K27ac.

2021-02-16 | GSE145891 | GEO

Gene Expression Profiles of Multiple Myeloma

Project description:Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients. Keywords = Multiple Myeloma, Bone Marrow, Pre-Treatment Keywords: other

2006-06-01 | GSE2658 | GEO

Transcription profiling of human newly diagnised multiple myeloma patients prior to treatment

Project description:Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients Experiment Overall Design: Samples in this series are: CD-138-selected plasma cells from bone marrow of newly diagnosed multiple myeloma patients susequently treated with Total Therapy

2008-06-13 | E-GEOD-4452 | biostudies-arrayexpress

Serum protein N-glycosylation changes in multiple myeloma

Project description:<h4><strong>BACKGROUND:</strong> Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies only detected limited serum N-glycan features.</h4><h4><strong>METHODS:</strong> Here, a more detailed study of the human serum N-glycome of 91 multiple myeloma patients and 51 controls was performed. We additionally analyzed sequential samples from patients (n = 7) which were obtained at different time points during disease development as well as 16 paired blood serum and bone marrow plasma samples. N-glycans were enzymatically released and measured by mass spectrometry after linkage specific derivatization of sialic acids.</h4><h4><strong>RESULTS:</strong> A decrease in both α2,3- and α2,6-sialylation, galactosylation and an increase in fucosylation within complex-type N-glycans were found in multiple myeloma patients compared to controls, as well as a decrease in difucosylation of diantennary glycans. The observed glycosylation changes were present in all ISS stages, including the 'low-risk' ISS I. In individual patients, difucosylation of diantennary glycans decreased with development of the disease. Protein N-glycosylation features from blood and bone marrow showed strong correlation. Moreover, associations of monoclonal immunoglobulin (M-protein) and albumin levels with glycan traits were discovered in multiple myeloma patients.</h4><h4><strong>CONCLUSIONS & GENERAL SIGNIFICANCE: </strong>In conclusion, serum protein N-glycosylation analysis could successfully distinguish multiple myeloma from healthy controls. Further studies are needed to assess the potential roles of glycan trait changes and the associations of glycans with clinical parameters in multiple myeloma early detection and prognosis.</h4>

2022-04-27 | MTBLS676 | MetaboLights

Gene Expression Profiles of Multiple Myeloma Before Treatment

Project description:Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients Keywords = CKS1B in Multiple Myeloma, Bone Marrow, Pre-Treatment Keywords: other

2006-06-01 | GSE4204 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data