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Identification of genes showing an age related expression in iNKT1, 2, and 17 cells of BALB/c thymus

ABSTRACT: In this study we applied RNA high-throughput seqencing to compare the global gene expression of young adult and aged iNKT subset in thymus of BALB/c mice. We found that only a small number of genes exerted a profound and statistically significant up- or downregulation upon ageing whereas a plethora of minor changes in the gene expression pattern were evident. However, significant age-related differences in expression of a variety of genes such as Histone genes, Gzma, CD25 and others might correlate with functional adaptations to the drastically altering thmyus micro-environment during aging.

ORGANISM(S): Mus musculus

PROVIDER: GSE147666 | GEO | 2020/10/26

REPOSITORIES: GEO

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