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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE147681 | GEO | 2021/03/23

REPOSITORIES: GEO

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ChIP-seq]

Project description:Sall4 is among one of the most important reprogramming factors. However, the underline molecular mechanisms for such importance remains unclear. In this report, we first described the gene expression and chromatin accessibility dynamics in OKS-Sall4 induced somatic cell reprogramming, and screened a group of downstream targets of Sall4, among which, cecr2, regulated by Sall4 directly, can significantly promote OKS induced reprogramming. Moreover, Cecr2 and Sall4 shared several downstream targets, such as Esrrb, Nanog, T etc., at transcription level when overexpress in the context of OKS induced reprogramming. We further showed that the DTT domain of cecr2 was responding to the reprogramming activity. Our findings provide a new important reprogramming factors and suggesting the cecr2-associted protein network may contributes to overcoming the epigenetic barriers in reprogramming.

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ATAC-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [RNA-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4

Project description:Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ATAC-seq]

Project description:Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ATAC-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [RNA-seq]

Project description:Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [RNA-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ChIP-seq]

Project description:Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ChIP-seq]

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The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure.

Project description:Somatic cells can be reprogrammed into pluripotent stem cells with a minimal set of defined factors, Oct3/4, Sox2, Klf4, and c-Myc, also known as OKSM, although this reprogramming is somewhat inefficient. Recent work has identified other nuclear factors, including SALL4, that can synergize with the OSK factors to improve reprogramming dynamics, but the specific role of each of these factors remains poorly understood. In this study, we sought to learn more about the role of SALL4. We observed that SALL4 was the most significant factor in promoting OKS-induced reprogramming. To look for molecules downstream of SALL4, we screened a set of putative targets to determine whether they could promote OKS-induced reprogramming. We identified CECR2, a multidomain nuclear factor and histone acetyl-lysine reader, as a SALL4 effector. Mechanistically, we determined that SALL4 activates Cecr2 expression by directly binding to its promotor region. CECR2 in turn promotes reprogramming by forming a chromatin remodeling complex; this complex contained the SWI/SNF family member SMARCA1 and was dependent on CECR2's DTT domain. In combination, our findings suggest that CECR2 is a novel reprogramming factor and works through a protein network to overcome epigenetic barriers during reprogramming.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-12 | GSE199614 | GEO